› 6zcg

Electron Microscopy
2.95Å resolution

Amyloid fibril morphology ii (in vitro) from murine SAA1.1 protein

Released:
DOI: 10.2210/pdb6zcg/pdb
PDB entry 6zcg coloured by chain, front view.
PDB entry 6zcg coloured by chain, side view.
PDB entry 6zcg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils.
Bansal A, Schmidt M, Rennegarbe M, Haupt C, Liberta F, Stecher S, Puscalau-Girtu I, Biedermann A, Fändrich M
Nat Commun 12 1013 (2021)
PMID: 33579941
Related structures: EMD-11163

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138643 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid A-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 103 amino acids
Theoretical weight: 11.62 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P05367 (Residues: 20-122; Coverage: 100%)
Gene name: Saa2
Sequence domains: Serum amyloid A protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.95Å
Relevant EMDB volumes: EMD-11163
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Beyond Amyloid Fibers: Accumulation, Biological Relevance, and Regulation of Higher-Order Prion Architectures.
Naeimi et al. (2022)
6 more

3 mentions without citation

Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis.
Lewkowicz et al. (2022)
2 more