› 6zfl

X-ray diffraction
1.6Å resolution

High resolution structure of VEGF-A 12:107 crystallized in tetragonal form

Released:
DOI: 10.2210/pdb6zfl/pdb
PDB entry 6zfl coloured by chain, front view.
PDB entry 6zfl coloured by chain, side view.
PDB entry 6zfl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Gaucher JF, Reille-Seroussi M, Broussy S
Chemistry e202200465 (2022)
PMID: 35665969

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147429 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-VEGF Chains: V, W
Molecule details ›
Chains: V, W
Length: 96 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15692 (Residues: 219-313; Coverage: 24%)
Gene names: VEGF, VEGFA

Ligands and Environments

2 bound ligands:
Ligand MPD 4 x MPD
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41
Unit cell:
a: 88.34Å b: 88.34Å c: 40.489Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.186
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 mentions without citation

Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments.
Wang et al. (2023)
6 more