› 6zfx

Electron Microscopy
2.88Å resolution

hSARM1 GraFix-ed

Released:
DOI: 10.2210/pdb6zfx/pdb
PDB entry 6zfx coloured by chain, front view.
PDB entry 6zfx coloured by chain, side view.
PDB entry 6zfx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny M, Guez-Haddad J, Khazma T, Yaron A, Dessau M, Shkolnisky Y, Mim C, Isupov MN, Zalk R, Hons M, Opatowsky Y
Elife 9 (2020)
PMID: 33185189
Related structures: EMD-11187

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 726 amino acids
Theoretical weight: 79.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6SZW1 (Residues: 26-724; Coverage: 97%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand S1N 16 x S1N
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.88Å
Relevant EMDB volumes: EMD-11187
Expression system: Homo sapiens

Quick links

Citations

16 review citations

Evolving concepts in NAD+ metabolism.
Chini et al. (2021)
15 more

1 mention without citation

Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny et al. (2020)