› 6zie

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167932 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CMPX-383B Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 14.95 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: B
Molecule details ›
Chain: B
Length: 162 amino acids
Theoretical weight: 18.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07820 (Residues: 172-327; Coverage: 45%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family

Ligands and Environments

1 bound ligand:
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P6122
Unit cell:
a: 69.699Å b: 69.699Å c: 261.289Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.24 0.259
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Understanding MCL1: from cellular function and regulation to pharmacological inhibition.
Sancho et al. (2022)
1 more

1 mention without citation

Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke et al. (2021)