› 6zjb

X-ray diffraction
1.82Å resolution

Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor Gp5A

Released:
DOI: 10.2210/pdb6zjb/pdb
Model geometry
Fit model/data
PDB entry 6zjb coloured by chain, front view.
PDB entry 6zjb coloured by chain, side view.
PDB entry 6zjb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3.
Rogne P, Dulko-Smith B, Goodman J, Rosselin M, Grundström C, Hedberg C, Nam K, Sauer-Eriksson AE, Wolf-Watz M
Biochemistry 59 3570-3581 (2020)
PMID: 32822537

Function and Biology Details

Reaction catalysed: 
NTP + AMP = NDP + ADP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTP:AMP phosphotransferase AK3, mitochondrial Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 227 amino acids
Theoretical weight: 25.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIJ7 (Residues: 1-227; Coverage: 100%)
Gene names: AK3, AK3L1, AK6, AKL3L
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand G5P 6 x G5P
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 45.468Å b: 66.76Å c: 105.909Å
α: 93.79° β: 93.95° γ: 89.71°
R-values:
R R work R free
0.195 0.192 0.256
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Adenylate Kinase Isozyme 3 Regulates Mitochondrial Energy Metabolism and Knockout Alters HeLa Cell Metabolism.
Fujisawa et al. (2022)
2 more

3 mentions without citation

Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets.
Jacobson et al. (2021)
2 more