6znm

Electron Microscopy
4.1Å resolution

The pointed end complex of dynactin bound to BICDR1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-104021 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
Alpha-centractin Chains: G, I
Molecule details ›
Chains: G, I
Length: 376 amino acids
Theoretical weight: 42.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F2Z5G5 (Residues: 1-310; Coverage: 89%)
Gene name: ACTR1A
Sequence domains: Actin
Actin, cytoplasmic 1 Chain: H
Molecule details ›
Chain: H
Length: 375 amino acids
Theoretical weight: 41.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q6QAQ1 (Residues: 1-375; Coverage: 100%)
Gene name: ACTB
Sequence domains: Actin
Actin-related protein 10 Chain: J
Molecule details ›
Chain: J
Length: 417 amino acids
Theoretical weight: 46.25 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LHK5 (Residues: 1-417; Coverage: 100%)
Gene names: ACTR10, ARP11
Sequence domains: Actin
Dynactin subunit 2 Chain: M
Molecule details ›
Chain: M
Length: 405 amino acids
Theoretical weight: 44.7 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A5G2QD80 (Residues: 1-405; Coverage: 100%)
Gene name: DCTN2
Sequence domains: Dynamitin
Dynactin subunit 6 Chain: U
Molecule details ›
Chain: U
Length: 190 amino acids
Theoretical weight: 20.7 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: D0G6S1 (Residues: 1-190; Coverage: 100%)
Gene name: DCTN6
Dynactin subunit 5 Chain: V
Molecule details ›
Chain: V
Length: 182 amino acids
Theoretical weight: 20.15 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZK88 (Residues: 1-182; Coverage: 100%)
Gene name: DCTN5
Sequence domains: Dynactin subunit 5
BICD family-like cargo adapter 1 Chains: X, x
Molecule details ›
Chains: X, x
Length: 577 amino acids
Theoretical weight: 58.42 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0JNT9 (Residues: 1-325; Coverage: 56%)
Gene names: Bicdl1, Bicdr1, Ccdc64
Dynactin subunit 4 Chain: Y
Molecule details ›
Chain: Y
Length: 467 amino acids
Theoretical weight: 52.92 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TB62 (Residues: 1-467; Coverage: 100%)
Gene name: DCTN4
Sequence domains: Dynactin p62 family

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-11317
Expression system: Spodoptera frugiperda