6zwo

Electron Microscopy
3Å resolution

cryo-EM structure of human mTOR complex 2, focused on one half

Released:
Source organism: Homo sapiens
Related structures: EMD-11492

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-154624 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine/threonine-protein kinase mTOR Chain: B
Molecule details ›
Chain: B
Length: 2549 amino acids
Theoretical weight: 289.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42345 (Residues: 1-2549; Coverage: 100%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Sequence domains:
Target of rapamycin complex subunit LST8 Chain: D
Molecule details ›
Chain: D
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BVC4 (Residues: 1-326; Coverage: 100%)
Gene names: GBL, LST8, MLST8
Sequence domains: WD domain, G-beta repeat
Rapamycin-insensitive companion of mTOR Chain: F
Molecule details ›
Chain: F
Length: 1708 amino acids
Theoretical weight: 192.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6R327 (Residues: 1-1708; Coverage: 100%)
Gene names: KIAA1999, RICTOR
Sequence domains:
Target of rapamycin complex 2 subunit MAPKAP1 Chain: H
Molecule details ›
Chain: H
Length: 521 amino acids
Theoretical weight: 59.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BPZ7 (Residues: 2-522; Coverage: 100%)
Gene names: MAPKAP1, MIP1, SIN1
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-11492
Expression system: Spodoptera frugiperda