› 7a3f

X-ray diffraction
2.9Å resolution

Crystal structure of apo DPP9

Released:
DOI: 10.2210/pdb7a3f/pdb
PDB entry 7a3f coloured by chain, front view.
PDB entry 7a3f coloured by chain, side view.
PDB entry 7a3f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ross BH, Huber R

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 9 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 898 amino acids
Theoretical weight: 102.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86TI2 (Residues: 1-863; Coverage: 100%)
Gene names: DPP9, DPRP2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 4 x PO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 95.17Å b: 95.31Å c: 127.196Å
α: 86.56° β: 102.54° γ: 102.44°
R-values:
R R work R free
0.226 0.223 0.29
Expression system: Spodoptera frugiperda

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