› 7a79

X-ray diffraction
2.05Å resolution

Crystal structure of RXR gamma LBD in complexes with palmitic acid and GRIP-1 peptide

Released:
DOI: 10.2210/pdb7a79/pdb
PDB entry 7a79 coloured by chain, front view.
PDB entry 7a79 coloured by chain, side view.
PDB entry 7a79 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, Merk D
Int J Mol Sci 21 (2020)
PMID: 33187070

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155732 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 233 amino acids
Theoretical weight: 26.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P48443 (Residues: 233-463; Coverage: 50%)
Gene names: NR2B3, RXRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor coactivator 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 14 amino acids
Theoretical weight: 1.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-699; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand PLM 2 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 63.246Å b: 67.051Å c: 110.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.248
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

3 citation in other articles

Structural overview and perspectives of the nuclear receptors, a major family as the direct targets for small-molecule drugs.
Li et al. (2022)
2 more

1 mention without citation

Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Chaikuad et al. (2020)