› 7a8u

X-ray diffraction
3.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152962 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-actinin-2 Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 56.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35609 (Residues: 274-746; Coverage: 53%)
Gene name: ACTN2
Sequence domains: Spectrin repeat
Myozenin-1 Chain: B
Molecule details ›
Chain: B
Length: 209 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NP98 (Residues: 92-299; Coverage: 70%)
Gene names: MYOZ, MYOZ1
Sequence domains: Calcineurin-binding protein (Calsarcin)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 101.65Å b: 101.65Å c: 218.65Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.239
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein condensation diseases: therapeutic opportunities.
Vendruscolo et al. (2022)
1 more