› 7acn

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURES OF ACONITASE WITH ISOCITRATE AND NITROISOCITRATE BOUND

Released:
DOI: 10.2210/pdb7acn/pdb
PDB entry 7acn coloured by chain, front view.
PDB entry 7acn coloured by chain, side view.
PDB entry 7acn coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structures of aconitase with isocitrate and nitroisocitrate bound.
Lauble H, Kennedy MC, Beinert H, Stout CD
Biochemistry 31 2735-48 (1992)
PMID: 1547214

Function and Biology Details

Reaction catalysed: 
(1a) citrate = cis-aconitate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aconitate hydratase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 754 amino acids
Theoretical weight: 82.79 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P16276 (Residues: 28-781; Coverage: 97%)
Gene name: ACO2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SF4 1 x SF4
Ligand ICT 1 x ICT
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Unit cell:
a: 185.5Å b: 72Å c: 73Å
α: 90° β: 90° γ: 77.7°
R-values:
R R work R free
0.179 0.179 not available
Expression system: Not provided

Quick links

Citations

17 review citations

Pathways of oxidative damage.
Imlay JA. (2003)
16 more

4 mentions without citation

An evolving view of complex II-noncanonical complexes, megacomplexes, respiration, signaling, and beyond.
Iverson et al. (2023)
3 more