› 7ah3

X-ray diffraction
1.95Å resolution

Kinase domain of cSrc in complex with a pyrazolopyrimidine

Released:
DOI: 10.2210/pdb7ah3/pdb
Model geometry
Fit model/data
PDB entry 7ah3 coloured by chain, front view.
PDB entry 7ah3 coloured by chain, side view.
PDB entry 7ah3 coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Dello Iacono L, Kleinboelting S, Fallacara AL, Rauh D

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

4 bound ligands:
Ligand RCK 2 x RCK
Ligand EDO 4 x EDO
Ligand DMS 1 x DMS
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 42.26Å b: 63.42Å c: 74.93Å
α: 101.722° β: 90.895° γ: 90.008°
R-values:
R R work R free
0.189 0.187 0.226
Expression system: Escherichia coli BL21

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