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› 7alk

X-ray diffraction
3Å resolution

Structure of Drosophila C2-DSL-EGF1

Released:
DOI: 10.2210/pdb7alk/pdb
Model geometry
Fit model/data
PDB entry 7alk coloured by chain, front view.
PDB entry 7alk coloured by chain, side view.
PDB entry 7alk coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.
Martins T, Meng Y, Korona B, Suckling R, Johnson S, Handford PA, Lea SM, Bray SJ
OpenAccess logo EMBO Rep 22 e52729 (2021)
PMID: 34347930

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145149 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neurogenic locus protein delta Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.42 KDa
Source organism: Drosophila melanogaster
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P10041 (Residues: 23-258; Coverage: 29%)
Gene names: CG3619, Delta, Dl
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 30.99Å b: 86.736Å c: 47.558Å
α: 90° β: 94.271° γ: 90°
R-values:
R R work R free
0.244 0.241 0.297
Expression system: Drosophila melanogaster

Quick links

Citations

1 review citation

Notch Signaling: An Emerging Paradigm in the Pathogenesis of Reproductive Disorders and Diverse Pathological Conditions.
Parambath et al. (2024)

1 mention without citation

The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.
Martins et al. (2021)