› 7anq

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226336 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 24.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 452-682; Coverage: 35%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
VHH P1.40 minibody anti-Cter PCSK9 Chain: B
Molecule details ›
Chain: B
Length: 127 amino acids
Theoretical weight: 14.34 KDa
Source organism: Lama glama
Expression system: Escherichia coli

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P41212
Unit cell:
a: 52.43Å b: 52.43Å c: 263.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.256
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

1 review citation

Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside.
Bao et al. (2024)
1 other article

1 mention without citation

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels.
Fruchart Gaillard et al. (2023)