7au2

Electron Microscopy
2.43Å resolution

Cryo-EM structure of human exostosin-like 3 (EXTL3)

Released:

Function and Biology Details

Reaction catalysed:
UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129158 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Exostosin-like 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 890 amino acids
Theoretical weight: 101.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43909 (Residues: 51-919; Coverage: 95%)
Gene names: EXTL1L, EXTL3, EXTR1, KIAA0519
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.43Å
Relevant EMDB volumes: EMD-11923
Expression system: Homo sapiens