› 7awd

X-ray diffraction
1.93Å resolution

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with garcinoic acid

Released:
DOI: 10.2210/pdb7awd/pdb
PDB entry 7awd coloured by chain, front view.
PDB entry 7awd coloured by chain, side view.
PDB entry 7awd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Endogenous vitamin E metabolites mediate allosteric PPARĪ³ activation with unprecedented co-regulatory interactions.
Willems S, Gellrich L, Chaikuad A, Kluge S, Werz O, Heering J, Knapp S, Lorkowski S, Schubert-Zsilavecz M, Merk D
Cell Chem Biol 28 1489-1500.e8 (2021)
PMID: 33989565

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

3 bound ligands:
Ligand NQD 2 x NQD
Ligand CIT 1 x CIT
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P43212
Unit cell:
a: 65.369Å b: 65.369Å c: 156.545Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Vitamin E (Alpha-Tocopherol) Metabolism and Nutrition in Chronic Kidney Disease.
Galli et al. (2022)
1 more

3 mentions without citation

Exploring the role of Xingren on COVID-19 based on network pharmacology and molecular docking.
Wang et al. (2022)
2 more