› 7azo

X-ray diffraction
3.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero 56-mer (preferred)
hetero 55-mer
Assembly name:
PDBe Complex ID:
PDB-CPX-143787 (preferred)
Entry contents:
48 distinct polypeptide molecules
9 distinct RNA molecules
Macromolecules (57 distinct):
Small ribosomal subunit protein uS2 Chains: S2A, S2B
Molecule details ›
Chains: S2A, S2B
Length: 256 amino acids
Theoretical weight: 29.32 KDa
Source organism: Thermus thermophilus HB8
UniProt:
  • Canonical: P80371 (Residues: 1-256; Coverage: 100%)
Gene names: TTHA0861, rps2, rpsB
Sequence domains: Ribosomal protein S2
Small ribosomal subunit protein uS3 Chains: S3A, S3B
Molecule details ›
Chains: S3A, S3B
Length: 239 amino acids
Theoretical weight: 26.75 KDa
Source organism: Thermus thermophilus HB8
UniProt:
  • Canonical: P80372 (Residues: 1-239; Coverage: 100%)
Gene names: TTHA1686, rps3, rpsC
Sequence domains:
Small ribosomal subunit protein uS4 Chains: S4A, S4B
Small ribosomal subunit protein uS5 Chains: S5A, S5B
Small ribosomal subunit protein bS6 Chains: S6A, S6B
Small ribosomal subunit protein uS7 Chains: S7A, S7B
Small ribosomal subunit protein uS8 Chains: S8A, S8B
Small ribosomal subunit protein uS9 Chains: S9A, S9B
Small ribosomal subunit protein uS10 Chains: S10A, S10B
Small ribosomal subunit protein uS11 Chains: S11A, S11B
Small ribosomal subunit protein uS12 Chains: S12A, S12B
Small ribosomal subunit protein uS13 Chains: S13A, S13B
Small ribosomal subunit protein uS14 Chains: S14A, S14B
Small ribosomal subunit protein uS15 Chains: S15A, S15B
Small ribosomal subunit protein bS16 Chains: S16A, S16B
Small ribosomal subunit protein uS17 Chains: S17A, S17B
Small ribosomal subunit protein bS18 Chains: S18A, S18B
Small ribosomal subunit protein uS19 Chains: S19A, S19B
Small ribosomal subunit protein bS20 Chains: S20A, S20B
Small ribosomal subunit protein bTHX Chains: THXA, THXB
Large ribosomal subunit protein uL2 Chains: L2A, L2B
Large ribosomal subunit protein uL3 Chains: L3A, L3B
Large ribosomal subunit protein uL4 Chains: L4A, L4B
Large ribosomal subunit protein uL5 Chains: L5A, L5B
Large ribosomal subunit protein uL6 Chains: L6A, L6B
Large ribosomal subunit protein bL9 Chains: L9A, L9B
Large ribosomal subunit protein uL13 Chains: L13A, L13B
Large ribosomal subunit protein uL14 Chains: L14A, L14B
Large ribosomal subunit protein uL15 Chains: L15A, L15B
Large ribosomal subunit protein uL16 Chains: L16A, L16B
Large ribosomal subunit protein bL17 Chains: L17A, L17B
Large ribosomal subunit protein uL18 Chains: L18A, L18B
Large ribosomal subunit protein bL19 Chains: L19A, L19B
Large ribosomal subunit protein bL20 Chains: L20A, L20B
Large ribosomal subunit protein bL21 Chains: L21A, L21B
Large ribosomal subunit protein uL22 Chains: L22A, L22B
Large ribosomal subunit protein uL23 Chains: L23A, L23B
Large ribosomal subunit protein uL24 Chains: L24A, L24B
Large ribosomal subunit protein bL25 Chains: L25A, L25B
Large ribosomal subunit protein bL27 Chains: L27A, L27B
Large ribosomal subunit protein bL28 Chains: L28A, L28B
Large ribosomal subunit protein uL29 Chains: L29A, L29B
Large ribosomal subunit protein uL30 Chains: L30A, L30B
Large ribosomal subunit protein bL31 Chains: L31A, L31B
Large ribosomal subunit protein bL32 Chains: L32A, L32B
Large ribosomal subunit protein bL33 Chains: L33A, L33B
Large ribosomal subunit protein bL34 Chains: L34A, L34B
Large ribosomal subunit protein bL35 Chains: L35A, L35B
16S ribosomal RNA Chains: 16SA, 16SB
Phe-tRNA Chain: ASIA
Phe-tRNA Chains: PSIA, PSIB
Phe-tRNA Chains: ESIA, ESIB
RNA (30-MER) Chains: MRNA, MRNB
Phe-tRNA Chain: TRNA
23S ribosomal RNA Chains: 23SA, 23SB
5S ribosomal RNA Chains: 5SA, 5SB
Phe-tRNA Chain: ASIB

Ligands and Environments

4 bound ligands:
Ligand MG 788 x MG
Ligand OHX 619 x OHX
Ligand K 287 x K
Ligand SJE 2 x SJE
18 modified residues:
Ligand PSU 22 x PSU
Ligand G7M 5 x G7M
Ligand M2G 2 x M2G
Ligand 5MC 12 x 5MC
Ligand 2MG 2 x 2MG
Ligand 4OC 2 x 4OC
Ligand UR3 2 x UR3
Ligand MA6 4 x MA6
Ligand 0TD 2 x 0TD
Ligand 4SU 4 x 4SU
Ligand MIA 7 x MIA
Ligand 5MU 9 x 5MU
Ligand H2U 4 x H2U
Ligand 3AU 2 x 3AU
Ligand OMC 2 x OMC
Ligand OMG 2 x OMG
Ligand 2MA 2 x 2MA
Ligand OMU 2 x OMU

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 209.77Å b: 446.87Å c: 616.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.238

Quick links

Citations

3 citation in other articles

Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity.
Tsirogianni et al. (2023)
2 more

1 mention without citation

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Zhang et al. (2023)