› 7b28

X-ray diffraction
2.1Å resolution

Complement inhibitor CirpA3 from Rhipicephalus pulchellus

Released:
DOI: 10.2210/pdb7b28/pdb
PDB entry 7b28 coloured by chain, front view.
PDB entry 7b28 coloured by chain, side view.
PDB entry 7b28 coloured by chain, top view.
Source organism: Rhipicephalus pulchellus
Primary publication:
Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Braunger K, Ahn J, Jore MM, Johnson S, Tang TTL, Pedersen DV, Andersen GR, Lea SM
Nat Commun 13 317 (2022)
PMID: 35031611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168026 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CirpA3 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 165 amino acids
Theoretical weight: 19.12 KDa
Source organism: Rhipicephalus pulchellus
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 68.366Å b: 150.298Å c: 68.43Å
α: 90° β: 91.833° γ: 90°
R-values:
R R work R free
0.222 0.217 0.25
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond.
Pedersen et al. (2023)
3 other articles