› 7b29

X-ray diffraction
1.83Å resolution

Complement inhibitor CirpA4 from Rhipicephalus appendiculatus

Released:
DOI: 10.2210/pdb7b29/pdb
PDB entry 7b29 coloured by chain, front view.
PDB entry 7b29 coloured by chain, side view.
PDB entry 7b29 coloured by chain, top view.
Source organism: Rhipicephalus appendiculatus
Primary publication:
Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Braunger K, Ahn J, Jore MM, Johnson S, Tang TTL, Pedersen DV, Andersen GR, Lea SM
Nat Commun 13 317 (2022)
PMID: 35031611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168027 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CirpA4 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 19.33 KDa
Source organism: Rhipicephalus appendiculatus
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand CD 3 x CD
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P212121
Unit cell:
a: 40.12Å b: 54.33Å c: 79.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.236
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond.
Pedersen et al. (2023)
3 other articles