› 7b2d

X-ray diffraction
1.96Å resolution

Complement inhibitor CirpA1 from Rhipicephalus pulchellus

Released:
DOI: 10.2210/pdb7b2d/pdb
PDB entry 7b2d coloured by chain, front view.
PDB entry 7b2d coloured by chain, side view.
PDB entry 7b2d coloured by chain, top view.
Source organism: Rhipicephalus pulchellus
Primary publication:
Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Braunger K, Ahn J, Jore MM, Johnson S, Tang TTL, Pedersen DV, Andersen GR, Lea SM
Nat Commun 13 317 (2022)
PMID: 35031611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168029 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CirpA1 Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.43 KDa
Source organism: Rhipicephalus pulchellus
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand MLT 2 x MLT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P2221
Unit cell:
a: 72.676Å b: 45.806Å c: 57.453Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.219
Expression system: Escherichia coli

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Citations

1 review citation

Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond.
Pedersen et al. (2023)
3 other articles