› 7b2w

X-ray diffraction
2.65Å resolution

Torpedo californica acetylcholinesterase complexed with UO2

Released:
DOI: 10.2210/pdb7b2w/pdb
PDB entry 7b2w coloured by chain, front view.
PDB entry 7b2w coloured by chain, side view.
PDB entry 7b2w coloured by chain, top view.
Source organism: Tetronarce californica
Primary publication:
Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Silman I, Shnyrov VL, Ashani Y, Roth E, Nicolas A, Sussman JL, Weiner L
Protein Sci 30 966-981 (2021)
PMID: 33686648

Function and Biology Details

Reaction catalysed: 
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137375 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 537 amino acids
Theoretical weight: 60.74 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P04058 (Residues: 22-558; Coverage: 95%)
Gene name: ache
Sequence domains: Carboxylesterase family

Ligands and Environments

1 bound ligand:
Ligand IUM 2 x IUM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P3121
Unit cell:
a: 110.88Å b: 110.88Å c: 134.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.161 0.212

Quick links

Citations

2 citation in other articles

GrAfSS: a webserver for substructure similarity searching and comparisons in the structures of proteins and RNA.
Ghani et al. (2022)
1 more

3 mentions without citation

Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Silman et al. (2021)
2 more