› 7b6f

X-ray diffraction
2.05Å resolution

GSK3-beta in complex with compound (S)-5c

Released:
DOI: 10.2210/pdb7b6f/pdb
Model geometry
Fit model/data
PDB entry 7b6f coloured by chain, front view.
PDB entry 7b6f coloured by chain, side view.
PDB entry 7b6f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tesch R, Andreev S, Koch P, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chain: A
Molecule details ›
Chain: A
Length: 365 amino acids
Theoretical weight: 41.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49841 (Residues: 26-383; Coverage: 85%)
Gene name: GSK3B
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand SZW 1 x SZW
Ligand EDO 2 x EDO
Ligand SO4 2 x SO4
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Unit cell:
a: 57.692Å b: 63.191Å c: 132.18Å
α: 90° β: 97.408° γ: 90°
R-values:
R R work R free
0.176 0.174 0.209
Expression system: Escherichia coli

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