› 7bb7

Electron Microscopy
4.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-208361 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Vasopressin V2 receptor Chain: A
Molecule details ›
Chain: A
Length: 440 amino acids
Theoretical weight: 47.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30518 (Residues: 3-30, 31-371; Coverage: 100%)
Gene names: ADHR, AVPR2, DIR, DIR3, V2R
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: C
Molecule details ›
Chain: C
Length: 371 amino acids
Theoretical weight: 40.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: E
Molecule details ›
Chain: E
Length: 394 amino acids
Theoretical weight: 45.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63092 (Residues: 1-394; Coverage: 100%)
Gene names: GNAS, GNAS1, GSP
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: F
Molecule details ›
Chain: F
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
Nanobody 35 Chain: G
Molecule details ›
Chain: G
Length: 138 amino acids
Theoretical weight: 15.14 KDa
Source organism: Lama glama
Expression system: Escherichia coli BL21(DE3)
Arg-vasopressin Chain: H
Molecule details ›
Chain: H
Length: 10 amino acids
Theoretical weight: 1.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01185 (Residues: 20-28; Coverage: 6%)
Gene names: ARVP, AVP, VP
Sequence domains: Neurohypophysial hormones, N-terminal Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-12129
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

2 review citations

Bringing GPCR Structural Biology to Medical Applications: Insights from Both V2 Vasopressin and Mu-Opioid Receptors.
Fouillen et al. (2023)
1 more

2 mentions without citation

Natural Peptide Toxins as an Option for Renewed Treatment of Type 2 Vasopressin Receptor-Related Diseases.
Gilles N. (2023)
1 more