7bgb

Electron Microscopy
3.39Å resolution

The H/ACA RNP lobe of human telomerase

Released:
Source organism: Homo sapiens
Related structures: EMD-12177

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-130097 (preferred)
Entry contents:
5 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (6 distinct):
Telomerase Cajal body protein 1 Chain: K
Molecule details ›
Chain: K
Length: 548 amino acids
Theoretical weight: 59.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BUR4 (Residues: 1-548; Coverage: 100%)
Gene names: TCAB1, WDR79, WRAP53
Sequence domains: WD domain, G-beta repeat
H/ACA ribonucleoprotein complex subunit DKC1 Chains: C, G
Molecule details ›
Chains: C, G
Length: 514 amino acids
Theoretical weight: 57.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60832 (Residues: 1-514; Coverage: 100%)
Gene names: DKC1, NOLA4
Sequence domains:
H/ACA ribonucleoprotein complex subunit 3 Chains: F, J
Molecule details ›
Chains: F, J
Length: 64 amino acids
Theoretical weight: 7.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NPE3 (Residues: 1-64; Coverage: 100%)
Gene names: NOLA3, NOP10
Sequence domains: Nucleolar RNA-binding protein, Nop10p family
H/ACA ribonucleoprotein complex subunit 1 Chains: D, H
Molecule details ›
Chains: D, H
Length: 217 amino acids
Theoretical weight: 22.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NY12 (Residues: 1-217; Coverage: 100%)
Gene names: GAR1, NOLA1
Sequence domains: Gar1/Naf1 RNA binding region
H/ACA ribonucleoprotein complex subunit 2 Chains: E, I
Molecule details ›
Chains: E, I
Length: 153 amino acids
Theoretical weight: 17.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NX24 (Residues: 1-153; Coverage: 100%)
Gene names: HSPC286, NHP2, NOLA2
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
RNA (92-MER) Chain: B
Molecule details ›
Chain: B
Length: 451 nucleotides
Theoretical weight: 145.48 KDa
Sequence domains: Vertebrate telomerase RNA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.39Å
Relevant EMDB volumes: EMD-12177