› 7bjg

X-ray diffraction
2.45Å resolution

Crystal structure of atypical Tm1 (Tm1-I/C), residues 262-363

Released:
DOI: 10.2210/pdb7bjg/pdb
PDB entry 7bjg coloured by chain, front view.
PDB entry 7bjg coloured by chain, side view.
PDB entry 7bjg coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.
Dimitrova-Paternoga L, Jagtap PKA, Cyrklaff A, Lapouge K, Sehr P, Perez K, Heber S, Löw C, Hennig J, Ephrussi A
Genes Dev 35 976-991 (2021)
PMID: 34140355

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184778 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tropomyosin 1, isoform E Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.92 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IGY1 (Residues: 487-588; Coverage: 14%)
Gene names: 1305/10, 2299, BcDNA:GH09289, BcDNA:LD37158, BcDNA:SD21996, CG4898, Dm Tm1, Dm TmH33, Dm TmH34, DmTm1, Dmel\CG4898, Dmel_CG4898, PmI, TM, TM1, TMII, Tm, Tm1, TmH, TmH-33, TmH-34, TmH33, TmH34, TmII, Tmr33, Tmr34, TnH, TnH-33, TnH-34, cTM, cTm, cTmII, chr3R:11122272..11122408, l(3)02299, l(3)S130510, l(3)s2958, mTmII, region 3, tm1, tmII, tropomyosin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P622
Unit cell:
a: 107.03Å b: 107.03Å c: 52.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.252 0.294
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Emerging Roles of RNA-Binding Proteins in Neurodevelopment.
Parra et al. (2022)
5 more

1 mention without citation

Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.
Dimitrova-Paternoga et al. (2021)