› 7bp3

Electron Microscopy
3.8Å resolution

Cryo-EM structure of the human MCT2

Released:
DOI: 10.2210/pdb7bp3/pdb
PDB entry 7bp3 coloured by chain, front view.
PDB entry 7bp3 coloured by chain, side view.
PDB entry 7bp3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cooperative transport mechanism of human monocarboxylate transporter 2.
Zhang B, Jin Q, Xu L, Li N, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N, Zhang X, Yang F, Guo J, Ye S
Nat Commun 11 2429 (2020)
PMID: 32415067
Related structures: EMD-30143

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monocarboxylate transporter 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 494 amino acids
Theoretical weight: 53.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60669 (Residues: 1-478; Coverage: 100%)
Gene names: MCT2, SLC16A7

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-30143
Expression system: Homo sapiens

Quick links

Citations

5 review citations

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.
Dvorak et al. (2021)
4 more

3 mentions without citation

Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS).
Drew et al. (2021)
2 more