› 7br3

X-ray diffraction
2.79Å resolution

Crystal structure of the protein 1

Released:
DOI: 10.2210/pdb7br3/pdb
PDB entry 7br3 coloured by chain, front view.
PDB entry 7br3 coloured by chain, side view.
PDB entry 7br3 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode.
Yan W, Cheng L, Wang W, Wu C, Yang X, Du X, Ma L, Qi S, Wei Y, Lu Z, Yang S, Shao Z
Nat Commun 11 5287 (2020)
PMID: 33082324

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gonadotropin-releasing hormone receptor; Starch synthase catalytic domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 528 amino acids
Theoretical weight: 60.28 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30968 (Residues: 1-242, 257-328; Coverage: 96%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: GNRHR, GRHR, PAB2292
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand 1QW 1 x 1QW
Ligand OLC 2 x OLC
Ligand PEG 6 x PEG
Ligand FMT 1 x FMT
Ligand F5O 1 x F5O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P3121
Unit cell:
a: 73.964Å b: 73.964Å c: 231.156Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.243 0.284
Expression system: Spodoptera frugiperda

Quick links

Citations

7 citation in other articles

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Yang et al. (2022)
6 more

11 mentions without citation

Allosteric communication regulates ligand-specific GPCR activity.
Ma et al. (2021)
10 more