› 7bv4

X-ray diffraction
2Å resolution

Crystal structure of STX17 LIR region in complex with GABARAP

Released:
DOI: 10.2210/pdb7bv4/pdb
Model geometry
Fit model/data
PDB entry 7bv4 coloured by chain, front view.
PDB entry 7bv4 coloured by chain, side view.
PDB entry 7bv4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
Li Y, Cheng X, Li M, Wang Y, Fu T, Zhou Z, Wang Y, Gong X, Xu X, Liu J, Pan L
Proc Natl Acad Sci U S A 117 21391-21402 (2020)
PMID: 32817423

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131849 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-aminobutyric acid receptor-associated protein Chains: A, B, E, G
Molecule details ›
Chains: A, B, E, G
Length: 117 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95166 (Residues: 1-117; Coverage: 100%)
Gene names: FLC3B, GABARAP, HT004
Sequence domains: Autophagy protein Atg8 ubiquitin like
Syntaxin-17 Chains: C, D, F, H
Molecule details ›
Chains: C, D, F, H
Length: 22 amino acids
Theoretical weight: 2.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56962 (Residues: 167-188; Coverage: 7%)
Gene name: STX17

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P41
Unit cell:
a: 42.943Å b: 42.943Å c: 245.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.225
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease.
Ihenacho et al. (2021)
2 more

1 mention without citation

Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52.
Fu et al. (2021)