› 7bx7

Electron Microscopy
2.8Å resolution

Cryo-EM structure of amyloid fibril formed by hnRNPA1 low complexity domain

Released:
DOI: 10.2210/pdb7bx7/pdb
PDB entry 7bx7 coloured by chain, front view.
PDB entry 7bx7 coloured by chain, side view.
PDB entry 7bx7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure.
Sun Y, Zhao K, Xia W, Feng G, Gu J, Ma Y, Gui X, Zhang X, Fang Y, Sun B, Wang R, Liu C, Li D
Nat Commun 11 6349 (2020)
PMID: 33311513
Related structures: EMD-30235

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140727 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 135 amino acids
Theoretical weight: 13.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09651 (Residues: 186-372; Coverage: 36%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: Heterogeneous nuclear ribonucleoprotein A1, LC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-30235
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Protein condensation diseases: therapeutic opportunities.
Vendruscolo et al. (2022)
3 more

4 mentions without citation

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Thibault et al. (2021)
3 more