› 7bz5

X-ray diffraction
1.84Å resolution

Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody

Released:
DOI: 10.2210/pdb7bz5/pdb
PDB entry 7bz5 coloured by chain, front view.
PDB entry 7bz5 coloured by chain, side view.
PDB entry 7bz5 coloured by chain, top view.
Source organisms:
Primary publication:
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Wu Y, Wang F, Shen C, Peng W, Li D, Zhao C, Li Z, Li S, Bi Y, Yang Y, Gong Y, Xiao H, Fan Z, Tan S, Wu G, Tan W, Lu X, Fan C, Wang Q, Liu Y, Zhang C, Qi J, Gao GF, Gao F, Liu L
Science 368 1274-1278 (2020)
PMID: 32404477

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209704 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.95 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Heavy chain of B38 Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of B38 Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 195.226Å b: 86.417Å c: 56.827Å
α: 90° β: 100.19° γ: 90°
R-values:
R R work R free
0.168 0.167 0.191
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

Quick links

Citations

140 review citations

Characteristics of SARS-CoV-2 and COVID-19.
Hu et al. (2021)
139 more

137 mentions without citation

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development.
Wang et al. (2020)
136 more