› 7c2l

Electron Microscopy
3.1Å resolution

S protein of SARS-CoV-2 in complex bound with 4A8

Released:
DOI: 10.2210/pdb7c2l/pdb
PDB entry 7c2l coloured by chain, front view.
PDB entry 7c2l coloured by chain, side view.
PDB entry 7c2l coloured by chain, top view.
Source organisms:
Primary publication:
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Chi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W
Science 369 650-655 (2020)
PMID: 32571838
Related structures: EMD-30276

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210138 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1283 amino acids
Theoretical weight: 142.5 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1273; Coverage: 100%)
Gene names: 2, S
Sequence domains:
heavy chain of 4A8 Chains: H, I, J
Molecule details ›
Chains: H, I, J
Length: 458 amino acids
Theoretical weight: 50.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain of 4A8 Chains: L, M, N
Molecule details ›
Chains: L, M, N
Length: 219 amino acids
Theoretical weight: 24.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 25 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-30276
Expression system: Homo sapiens

Quick links

Citations

186 review citations

SARS-CoV-2 variants, spike mutations and immune escape.
Harvey et al. (2021)
185 more

108 mentions without citation

The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies.
Papageorgiou et al. (2020)
107 more