› 7c44

X-ray diffraction
1.65Å resolution

Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a

Released:
DOI: 10.2210/pdb7c44/pdb
PDB entry 7c44 coloured by chain, front view.
PDB entry 7c44 coloured by chain, side view.
PDB entry 7c44 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Cheng XY, Zhang BL, Kuang ZK, Yang J, Li ZC, Yu JP, Zhao ZT, Cao CZ, Su ZD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: O15151 (Residues: 23-108; Coverage: 18%)
Gene names: MDM4, MDMX

Ligands and Environments

2 bound ligands:
Ligand NUT 1 x NUT
Ligand O4B 1 x O4B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P43212
Unit cell:
a: 47.47Å b: 47.47Å c: 91.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.265
Expression system: Escherichia coli K-12

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