› 7c72

X-ray diffraction
3Å resolution

Structure of a mycobacterium tuberculosis puromycin-hydrolyzing peptidase

Released:
DOI: 10.2210/pdb7c72/pdb
PDB entry 7c72 coloured by chain, front view.
PDB entry 7c72 coloured by chain, side view.
PDB entry 7c72 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity.
Zhao Y, Feng Q, Zhou X, Zhang Y, Lukman M, Jiang J, Ruiz-Carrillo D
Proteins 89 614-622 (2021)
PMID: 33426726

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168104 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prolyl oligopeptidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 696 amino acids
Theoretical weight: 75.5 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand MLT 1 x MLT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P63
Unit cell:
a: 183.95Å b: 183.95Å c: 146.31Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.218
Expression system: Escherichia coli BL21(DE3)

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