7c7q

Electron Microscopy
3Å resolution

Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state

Released:
Source organism: Homo sapiens
Related structures: EMD-30300

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-131164 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-aminobutyric acid type B receptor subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 879 amino acids
Theoretical weight: 99.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UBS5 (Residues: 15-862; Coverage: 90%)
Gene names: GABBR1, GPRC3A
Sequence domains:
Gamma-aminobutyric acid type B receptor subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 769 amino acids
Theoretical weight: 86.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75899 (Residues: 41-780; Coverage: 82%)
Gene names: GABBR2, GPR51, GPRC3B
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-30300
Expression system: Homo sapiens