› 7c8l

X-ray diffraction
1.45Å resolution

Hybrid designing of potent inhibitors of Striga strigolactone receptor ShHTL7

Released:
DOI: 10.2210/pdb7c8l/pdb
PDB entry 7c8l coloured by chain, front view.
PDB entry 7c8l coloured by chain, side view.
PDB entry 7c8l coloured by chain, top view.
Source organism: Striga hermonthica
Primary publication:
Rational design of Striga hermonthica-specific seed germination inhibitors.
Zarban RA, Hameed UFS, Jamil M, Ota T, Wang JY, Arold ST, Asami T, Al-Babili S
Plant Physiol 188 1369-1384 (2022)
PMID: 34850204

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102500 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AB hydrolase-1 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 30.61 KDa
Source organism: Striga hermonthica
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0M3PNA2 (Residues: 1-271; Coverage: 100%)
Sequence domains: Alpha/beta hydrolase family

Ligands and Environments

4 bound ligands:
Ligand EGC 1 x EGC
Ligand SO4 2 x SO4
Ligand GOL 1 x GOL
Ligand FP6 1 x FP6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P65
Unit cell:
a: 92.474Å b: 92.474Å c: 80.256Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.136 0.136 0.168
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Host Resistance to Parasitic Plants-Current Knowledge and Future Perspectives.
Albanova et al. (2023)
3 other articles

1 mention without citation

Rational design of Striga hermonthica-specific seed germination inhibitors.
Zarban et al. (2022)