› 7ceg

X-ray diffraction
3.85Å resolution

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179140 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Receptor-type tyrosine-protein phosphatase delta Chain: A
Molecule details ›
Chain: A
Length: 386 amino acids
Theoretical weight: 42.38 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64487 (Residues: 21-411; Coverage: 20%)
Gene name: Ptprd
Sequence domains:
Neuroligin-3 Chain: B
Molecule details ›
Chain: B
Length: 579 amino acids
Theoretical weight: 64.51 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BYM5 (Residues: 37-615; Coverage: 73%)
Gene name: Nlgn3
Sequence domains: Carboxylesterase family

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P3212
Unit cell:
a: 96.109Å b: 96.109Å c: 371.613Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.253 0.289
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction.
Uchigashima et al. (2021)
4 more