7cgp

Electron Microscopy
3.7Å resolution

Cryo-EM structure of the human mitochondrial translocase TIM22 complex at 3.7 angstrom.

Released:
Source organism: Homo sapiens
Related structures: EMD-9958

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-158543 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Mitochondrial import inner membrane translocase subunit Tim22 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 20.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y584 (Residues: 1-194; Coverage: 100%)
Gene names: TEX4, TIM22, TIMM22
Sequence domains: Tim17/Tim22/Tim23/Pmp24 family
Acylglycerol kinase, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 422 amino acids
Theoretical weight: 47.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q53H12 (Residues: 1-422; Coverage: 100%)
Gene names: AGK, MULK
Sequence domains:
Mitochondrial import inner membrane translocase subunit Tim29 Chain: C
Molecule details ›
Chain: C
Length: 260 amino acids
Theoretical weight: 29.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSF4 (Residues: 1-260; Coverage: 100%)
Gene names: TIMM29, c19orf52
Sequence domains: Translocase of the Inner Mitochondrial membrane 29
Mitochondrial import inner membrane translocase subunit Tim9 Chains: D, E, F, K, L
Molecule details ›
Chains: D, E, F, K, L
Length: 89 amino acids
Theoretical weight: 10.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5J7 (Residues: 1-89; Coverage: 100%)
Gene names: TIM9, TIM9A, TIMM9, TIMM9A
Sequence domains: Tim10/DDP family zinc finger
Mitochondrial import inner membrane translocase subunit Tim10 Chains: G, H, I, M, N, O
Molecule details ›
Chains: G, H, I, M, N, O
Length: 90 amino acids
Theoretical weight: 10.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62072 (Residues: 1-90; Coverage: 100%)
Gene names: TIM10, TIMM10
Sequence domains: Tim10/DDP family zinc finger
Mitochondrial import inner membrane translocase subunit Tim10 B Chain: J
Molecule details ›
Chain: J
Length: 103 amino acids
Theoretical weight: 11.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5J6 (Residues: 1-103; Coverage: 100%)
Gene names: FXC1, TIM9B, TIMM10B, TIMM9B
Sequence domains: Tim10/DDP family zinc finger

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-9958
Expression system: Homo sapiens