› 7chb

X-ray diffraction
2.4Å resolution

Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab

Released:
DOI: 10.2210/pdb7chb/pdb
Model geometry
Fit model/data
PDB entry 7chb coloured by chain, front view.
PDB entry 7chb coloured by chain, side view.
PDB entry 7chb coloured by chain, top view.
Source organisms:
Primary publication:
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Du S, Cao Y, Zhu Q, Yu P, Qi F, Wang G, Du X, Bao L, Deng W, Zhu H, Liu J, Nie J, Zheng Y, Liang H, Liu R, Gong S, Xu H, Yisimayi A, Lv Q, Wang B, He R, Han Y, Zhao W, Bai Y, Qu Y, Gao X, Ji C, Wang Q, Gao N, Huang W, Wang Y, Xie XS, Su XD, Xiao J, Qin C
OpenAccess logo Cell 183 1013-1023.e13 (2020)
PMID: 32970990

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209714 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
BD-236 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BD-236 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chain: R

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 195.614Å b: 86.788Å c: 56.415Å
α: 90° β: 100.13° γ: 90°
R-values:
R R work R free
0.194 0.192 0.226
Expression systems:
  • Homo sapiens
  • Spodoptera frugiperda

Quick links

Citations

35 review citations

Viral targets for vaccines against COVID-19.
Dai et al. (2021)
34 more

24 mentions without citation

Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies.
Yuan et al. (2021)
23 more