› 7cio

X-ray diffraction
1.1Å resolution

Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase

Released:
DOI: 10.2210/pdb7cio/pdb
PDB entry 7cio coloured by chain, front view.
PDB entry 7cio coloured by chain, side view.
PDB entry 7cio coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Iiyama M, Numoto N, Ogawa S, Kuroda M, Morii H, Abe R, Ito N, Oda M
Mol Immunol 131 51-59 (2021)
PMID: 33386150

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147703 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P27986 (Residues: 614-720; Coverage: 15%)
Gene names: GRB1, PIK3R1
Sequence domains: SH2 domain
Cytotoxic T-lymphocyte protein 4 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 971 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16410 (Residues: 199-206; Coverage: 4%)
Gene names: CD152, CTLA4

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 41.221Å b: 41.563Å c: 59.628Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.154 0.179
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

3 citation in other articles

CTLA-4 Facilitates DNA Damage-Induced Apoptosis by Interacting With PP2A.
Yan et al. (2022)
2 more

1 mention without citation

Atraric Acid Ameliorates Hyperpigmentation through the Downregulation of the PKA/CREB/MITF Signaling Pathway.
Li et al. (2022)