› 7cm1

X-ray diffraction
2.14Å resolution

Neuraminidase from the Wuhan Asiatic toad influenza virus

Released:
DOI: 10.2210/pdb7cm1/pdb
PDB entry 7cm1 coloured by chain, front view.
PDB entry 7cm1 coloured by chain, side view.
PDB entry 7cm1 coloured by chain, top view.
Source organism: Wuhan asiatic toad influenza virus
Primary publication:
Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase.
Li L, Dai S, Gao GF, Wang J
Acta Crystallogr D Struct Biol 76 1057-1064 (2020)
PMID: 33135677

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 387 amino acids
Theoretical weight: 41.99 KDa
Source organism: Wuhan asiatic toad influenza virus
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: A0A2P1GNT2 (Residues: 80-466; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand G39 2 x G39
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2221
Unit cell:
a: 119.966Å b: 143.148Å c: 120.097Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.28
Expression system: Insect cell expression vector pTIE1

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Citations

1 review citation

Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase.
Jiang et al. (2023)
1 other article