Function and Biology Details
Reaction catalysed:
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- NAD(P)-binding domain superfamily
- Trans-enoyl reductase-like
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Polyketide synthase, dehydratase domain
- Acyl transferase
- Polyketide synthase, beta-ketoacyl synthase domain
- Thiolase-like
- Alcohol dehydrogenase-like, N-terminal
17 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Lovastatin nonaketide synthase, (preferred)
PDBe Complex ID:
PDB-CPX-195405 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lovastatin nonaketide synthase, enoyl reductase component lovC
Molecule details ›
Chains: C, D
Length: 371 amino acids
Theoretical weight: 40.62 KDa
Source organism: Aspergillus terreus
Expression system: Escherichia coli
UniProt:
Sequence domains: Alcohol dehydrogenase GroES-like domain
Length: 371 amino acids
Theoretical weight: 40.62 KDa
Source organism: Aspergillus terreus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9Y7D0 (Residues: 1-363; Coverage: 100%)
Sequence domains: Alcohol dehydrogenase GroES-like domain
Lovastatin nonaketide synthase, polyketide synthase component
Molecule details ›
Chains: A, B
Length: 3046 amino acids
Theoretical weight: 336.45 KDa
Source organism: Aspergillus terreus
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 3046 amino acids
Theoretical weight: 336.45 KDa
Source organism: Aspergillus terreus
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: Q9Y8A5 (Residues: 1-3038; Coverage: 100%)
Sequence domains:
- Beta-ketoacyl synthase, N-terminal domain
- Beta-ketoacyl synthase, C-terminal domain
- Ketoacyl-synthetase C-terminal extension
- Acyl transferase domain
- Polyketide synthase dehydratase domain
- Polyketide synthase dehydratase N-terminal domain
- Methyltransferase domain
- KR domain
- Phosphopantetheine attachment site
- Condensation domain
