› 7cr3

Electron Microscopy
3.6Å resolution

human KCNQ2-CaM in apo state

Released:
DOI: 10.2210/pdb7cr3/pdb
PDB entry 7cr3 coloured by chain, front view.
PDB entry 7cr3 coloured by chain, side view.
PDB entry 7cr3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for ligand activation of the human KCNQ2 channel.
Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J
Cell Res 31 52-61 (2021)
PMID: 32884139
Related structures: EMD-30446

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128989 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 2 Chains: A, B, D, G
Molecule details ›
Chains: A, B, D, G
Length: 656 amino acids
Theoretical weight: 73.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43526 (Residues: 64-702; Coverage: 73%)
Gene name: KCNQ2
Sequence domains:
Calmodulin-3 Chains: C, E, F, H
Molecule details ›
Chains: C, E, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0DP25 (Residues: 1-149; Coverage: 100%)
Gene names: CALM3, CALML2, CAM3, CAMC, CAMIII
Sequence domains: EF-hand domain pair

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-30446
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Chemical modulation of Kv7 potassium channels.
Borgini et al. (2021)
2 more

8 mentions without citation

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Willegems et al. (2022)
7 more