› 7crw

Electron Microscopy
3.18Å resolution

Cryo-EM structure of rNLRP1-rDPP9 complex

Released:
DOI: 10.2210/pdb7crw/pdb
PDB entry 7crw coloured by chain, front view.
PDB entry 7crw coloured by chain, side view.
PDB entry 7crw coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J
Nature 592 773-777 (2021)
PMID: 33731929
Related structures: EMD-30458

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112923 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
dipeptidyl-peptidase IV Chains: C, D
Molecule details ›
Chains: C, D
Length: 862 amino acids
Theoretical weight: 98.2 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: M0R781 (Residues: 13-874; Coverage: 99%)
Gene name: Dpp9
Sequence domains:
NACHT, LRR and PYD domains-containing protein 1a allele 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1218 amino acids
Theoretical weight: 138.58 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: D9I2F9 (Residues: 1-1218; Coverage: 100%)
Gene names: Nlrp1, Nlrp1a
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.18Å
Relevant EMDB volumes: EMD-30458
Expression system: Spodoptera frugiperda

Quick links

Citations

31 review citations

Programming inflammatory cell death for therapy.
Christgen et al. (2022)
30 more

1 mention without citation

Residue-wise local quality estimation for protein models from cryo-EM maps.
Terashi et al. (2022)