› 7crz

X-ray diffraction
2.3Å resolution

Crystal structure of human glucose transporter GLUT3 bound with C3361

Released:
DOI: 10.2210/pdb7crz/pdb
PDB entry 7crz coloured by chain, front view.
PDB entry 7crz coloured by chain, side view.
PDB entry 7crz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents.
Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H
Proc Natl Acad Sci U S A 118 (2021)
PMID: 33402433

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 2, facilitated glucose transporter member 3 Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 56.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11169 (Residues: 1-496; Coverage: 100%)
Gene names: GLUT3, SLC2A3
Sequence domains: Sugar (and other) transporter

Ligands and Environments

2 bound ligands:
Ligand F00 1 x F00
Ligand OLC 6 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P21
Unit cell:
a: 48.329Å b: 118.248Å c: 54.252Å
α: 90° β: 103.54° γ: 90°
R-values:
R R work R free
0.168 0.166 0.212
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Discovery and Development of Inhibitors of the Plasmodial FNT-Type Lactate Transporter as Novel Antimalarials.
Nerlich et al. (2021)
1 more

1 mention without citation

An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions.
Jiang X. (2022)