7cu3

Electron Microscopy
2.65Å resolution

Structure of mammalian NALCN-FAM155A complex at 2.65 angstrom

Released:
Source organisms:
Primary publication:
Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
Nat Commun 11 6199 (2020)
PMID: 33273469
Related structures: EMD-30470

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-180244 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium leak channel NALCN Chain: A
Molecule details ›
Chain: A
Length: 1738 amino acids
Theoretical weight: 200.68 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6Q760 (Residues: 1-1738; Coverage: 100%)
Gene names: Nalcn, Nca, Rb21, Vgcnl1
Sequence domains: Ion transport protein
NALCN channel auxiliary factor 1 Chain: B
Molecule details ›
Chain: B
Length: 467 amino acids
Theoretical weight: 52.8 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8CCS2 (Residues: 1-467; Coverage: 100%)
Gene names: Fam155a, Nalf1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.65Å
Relevant EMDB volumes: EMD-30470
Expression system: Homo sapiens