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› 7cwu

Electron Microscopy
3.5Å resolution

SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail

Released:
DOI: 10.2210/pdb7cwu/pdb
PDB entry 7cwu coloured by chain, front view.
PDB entry 7cwu coloured by chain, side view.
PDB entry 7cwu coloured by chain, top view.
Source organisms:
Primary publication:
Structure-based development of human antibody cocktails against SARS-CoV-2.
Wang N, Sun Y, Feng R, Wang Y, Guo Y, Zhang L, Deng YQ, Wang L, Cui Z, Cao L, Zhang YJ, Li W, Zhu FC, Qin CF, Wang X
OpenAccess logo Cell Res 31 101-103 (2021)
PMID: 33262454
Related structures: EMD-30488

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279711 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
heavy chain of FC05 Fab Chains: J, N, P
Molecule details ›
Chains: J, N, P
Length: 120 amino acids
Theoretical weight: 13.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain of FC05 Fab Chains: F, G, I
Molecule details ›
Chains: F, G, I
Length: 109 amino acids
Theoretical weight: 11.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike glycoprotein Chains: A, B, C
heavy chain of P17 Fab Chains: H, M, O
light chain of P17 Fab Chains: L, R, S

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 16 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.5Å
Relevant EMDB volumes: EMD-30488
Expression system: Homo sapiens

Quick links

Citations

12 review citations

Structural biology of SARS-CoV-2 and implications for therapeutic development.
Yang et al. (2021)
11 more

17 mentions without citation

SARS-CoV-2 Omicron Variant: Epidemiological Features, Biological Characteristics, and Clinical Significance.
Guo et al. (2022)
16 more