› 7d10

Electron Microscopy
3.52Å resolution

Human NKCC1

Released:
DOI: 10.2210/pdb7d10/pdb
PDB entry 7d10 coloured by chain, front view.
PDB entry 7d10 coloured by chain, side view.
PDB entry 7d10 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2.
Zhang S, Zhou J, Zhang Y, Liu T, Friedel P, Zhuo W, Somasekharan S, Roy K, Zhang L, Liu Y, Meng X, Deng H, Zeng W, Li G, Forbush B, Yang M
OpenAccess logo Commun Biol 4 226 (2021)
PMID: 33597714
Related structures: EMD-30542

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157148 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 12 member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1212 amino acids
Theoretical weight: 131.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55011 (Residues: 1-1212; Coverage: 100%)
Gene names: NKCC1, SLC12A2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PLM 4 x PLM
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.52Å
Relevant EMDB volumes: EMD-30542
Expression system: Homo sapiens

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Citations

14 review citations

Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited.
MacAulay et al. (2022)
13 more

19 mentions without citation

Cation-coupled chloride cotransporters: chemical insights and disease implications.
Portioli et al. (2021)
18 more