› 7d3k

Electron Microscopy
3.9Å resolution

FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY B77

Released:
DOI: 10.2210/pdb7d3k/pdb
PDB entry 7d3k coloured by chain, front view.
PDB entry 7d3k coloured by chain, side view.
PDB entry 7d3k coloured by chain, top view.
Source organisms:
Primary publication:
Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization.
He Y, Li K, Cao Y, Sun Z, Li P, Bao H, Wang S, Zhu G, Bai X, Sun P, Liu X, Yang C, Liu Z, Lu Z, Rao Z, Lou Z
OpenAccess logo PLoS Pathog 17 e1009507 (2021)
PMID: 33909694
Related structures: EMD-30558

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 360-mer (preferred)
PDBe Complex ID:
PDB-CPX-207375 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 213 amino acids
Theoretical weight: 23.52 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: G3E3P7 (Residues: 1-213; Coverage: 100%)
Sequence domains: Picornavirus coat protein
VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 218 amino acids
Theoretical weight: 24.34 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: Q06F56 (Residues: 1-218; Coverage: 100%)
Sequence domains: picornavirus capsid protein
Capsid protein Chain: 3
Molecule details ›
Chain: 3
Length: 220 amino acids
Theoretical weight: 23.88 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: A0A1C6ZW60 (Residues: 304-523; Coverage: 30%)
Sequence domains: picornavirus capsid protein
O/TIBET/99 VP4 Chain: 4
Molecule details ›
Chain: 4
Length: 85 amino acids
Theoretical weight: 8.78 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: P87677 (Residues: 1-85; Coverage: 12%)
Sequence domains: Viral protein VP4 subunit
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 124 amino acids
Theoretical weight: 13.33 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A6B9SBE3 (Residues: 1-124; Coverage: 100%)
Sequence domains: Immunoglobulin V-set domain
B77 VL Chain: L
Molecule details ›
Chain: L
Length: 123 amino acids
Theoretical weight: 12.95 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.9Å
Relevant EMDB volumes: EMD-30558
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Development of Foot-and-Mouth Disease Vaccines in Recent Years.
Lu et al. (2022)
6 other articles

2 mentions without citation

Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization.
He et al. (2021)
1 more