› 7d8s

X-ray diffraction
2.28Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microphthalmia-associated transcription factor; tRNA-binding domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 199 amino acids
Theoretical weight: 22.77 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: O75030 (Residues: 306-395; Coverage: 17%)
  • Canonical: O66738 (Residues: 8-111; Coverage: 94%)
Gene names: BHLHE32, MITF, aq_422, metG'
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P1
Unit cell:
a: 56.005Å b: 62.306Å c: 65.307Å
α: 90.12° β: 72.74° γ: 86.39°
R-values:
R R work R free
0.233 0.231 0.27
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses.
Wei et al. (2023)
1 more

1 mention without citation

A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Liu et al. (2023)