› 7da4

Electron Microscopy
4.24Å resolution

Cryo-EM structure of amyloid fibril formed by human RIPK3

Released:
DOI: 10.2210/pdb7da4/pdb
PDB entry 7da4 coloured by chain, front view.
PDB entry 7da4 coloured by chain, side view.
PDB entry 7da4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3.
Wu X, Ma Y, Zhao K, Zhang J, Sun Y, Li Y, Dong X, Hu H, Liu J, Wang J, Zhang X, Li B, Wang H, Li D, Sun B, Lu J, Liu C
Proc Natl Acad Sci U S A 118 (2021)
PMID: 33790016
Related structures: EMD-30622

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195262 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-interacting serine/threonine-protein kinase 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 141 amino acids
Theoretical weight: 15.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y572 (Residues: 388-518; Coverage: 25%)
Gene names: RIP3, RIPK3
Sequence domains: RIP homotypic interaction motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.24Å
Relevant EMDB volumes: EMD-30622
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Cryo-EM of Helical Polymers.
Wang et al. (2022)
3 more

1 mention without citation

The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3.
Wu et al. (2021)